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Axolotl problems
As Mexico City grew and became more industrialized, the need for water brought pumps and pipes to the lake, and eventually, “it was like a bad, smelly pond with rotten water,” Zambrano said. “All of our aquatic animals suffer with bad water quality, but amphibians suffer more because they have to breathe with the skin.”
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To add to the axolotls’ problems, invasive fish species such as carp and tilapia were introduced to the lake, where they feed on axolotl eggs. And a 1985 earthquake in Mexico City displaced thousands of people, who found new homes in the area around the lake, further contributing to the destruction of the axolotls’ habitat.

These combined threats have devastated axolotl populations. According to the International Union for Conservation of Nature, there are fewer than 100 adult axolotls left in the wild. The species is considered critically endangered.
While the wild axolotls of Lake Xochimilco have dwindled to near-extinction, countless axolotls have been bred for scientific laboratories and the pet trade. “The axolotl essentially helped establish the field of experimental zoology,” Voss said.

In 1864, a French army officer brought live axolotls back to Europe, where scientists were surprised to learn that the seemingly juvenile aquatic salamanders were capable of reproduction. Since then, scientists around the world have studied axolotls and their DNA to learn about the salamanders’ unusual metamorphosis (or lack thereof) as well as their ability to regrow injured body parts.
In addition to their role in labs, axolotls have become popular in the exotic pet trade (though they are illegal to own in California, Maine, New Jersey and Washington, DC). However, the axolotls you might find at a pet shop are different from their wild relatives in Lake Xochimilco. Most wild axolotls are a dark grayish brown. The famous pink axolotls, as well as other color variants such as white, blue, yellow and black, are genetic anomalies that are rare in the wild but selectively bred for in the pet trade.

What’s more, “most of the animals in the pet trade have a very small genetic variance,” Zambrano said. Pet axolotls tend to be inbred and lack the wide flow of different genes that makes up a healthy population in the wild. That means that the axolotl extinction crisis can’t simply be solved by dumping pet axolotls into Lake Xochimilco. (Plus, the pet axolotls likely wouldn’t fare well with the poor habitat conditions in the lake.)

Fame and misfortune
The difficulties that axolotls face in the wild are almost diametrically opposed to the fame they’ve found in recent years. Axolotls have captured the human imagination for centuries, as evidenced by their roles in Aztec religion and stories, but the early 21st century seems to be a high point for them. An axolotl graces the 50 peso bill. There are axolotl-inspired Pokemon, and Reddit commenters have noted that the character Toothless from the “How to Train Your Dragon” movie series is distinctly axolotl-like.

The introduction of axolotls to Minecraft in 2021 neatly mapped onto an uptick in Google searches for the animals, and social media makes it easy for people to gain access to photos and videos of the salamanders, particularly the photogenic pink ones often kept as pets.

The axolotl pet trade probably doesn’t directly harm the wild populations since wild salamanders aren’t being poached or taken from Lake Xochimilco. However, Zambrano said, axolotls’ ubiquity in pop culture and pet stores might make people assume that because axolotls “live in all the tanks around the world, they are not in danger.”

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Why axolotls seem to be everywhere — except in the one lake they call home
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Scientist Dr. Randal Voss gets the occasional reminder that he’s working with a kind of superstar. When he does outreach events with his laboratory, he encounters people who are keen to meet his research subjects: aquatic salamanders called axolotls.

The amphibians’ fans tell Voss that they know the animals from the internet, or from caricatures or stuffed animals, exclaiming, “‘They’re so adorable, we love them,’” said Voss, a professor of neuroscience at the University of Kentucky College of Medicine. “People are drawn to them.”

Take one look at an axolotl, and it’s easy to see why it’s so popular. With their wide eyes, upturned mouths and pastel pink coloring, axolotls look cheerful and vaguely Muppet-like.

They’ve skyrocketed in pop culture fame, in part thanks to the addition of axolotls to the video game Minecraft in 2021. These unusual salamanders are now found everywhere from Girl Scout patches to hot water bottles. But there’s more to axolotls than meets the eye: Their story is one of scientific discovery, exploitation of the natural world, and the work to rebuild humans’ connection with nature.

A scientific mystery
Axolotl is a word from Nahuatl, the Indigenous Mexican language spoken by the Aztecs and an estimated 1.5 million people today. The animals are named for the Aztec god Xolotl, who was said to transform into a salamander. The original Nahuatl pronunciation is “AH-show-LOAT”; in English, “ACK-suh-LAHT-uhl” is commonly used.
Axolotls are members of a class of animals called amphibians, which also includes frogs. Amphibians lay their jelly-like eggs in water, and the eggs hatch into water-dwelling larval states. (In frogs, these larvae are called tadpoles.)

Most amphibians, once they reach adulthood, are able to move to land. Since they breathe, in part, by absorbing oxygen through their moist skin, they tend to stay near water.

Axolotls, however, never complete the metamorphosis to a land-dwelling adult form and spend their whole lives in the water.

“They maintain their juvenile look throughout the course of their life,” Voss said. “They’re teenagers, at least in appearance, until they die.”

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Mist and microlightning
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To recreate a scenario that may have produced Earth’s first organic molecules, researchers built upon experiments from 1953 when American chemists Stanley Miller and Harold Urey concocted a gas mixture mimicking the atmosphere of ancient Earth. Miller and Urey combined ammonia (NH3), methane (CH4), hydrogen (H2) and water, enclosed their “atmosphere” inside a glass sphere and jolted it with electricity, producing simple amino acids containing carbon and nitrogen. The Miller-Urey experiment, as it is now known, supported the scientific theory of abiogenesis: that life could emerge from nonliving molecules.
For the new study, scientists revisited the 1953 experiments but directed their attention toward electrical activity on a smaller scale, said senior study author Dr. Richard Zare, the Marguerite Blake Wilbur Professor of Natural Science and professor of chemistry at Stanford University in California. Zare and his colleagues looked at electricity exchange between charged water droplets measuring between 1 micron and 20 microns in diameter. (The width of a human hair is 100 microns.)

“The big droplets are positively charged. The little droplets are negatively charged,” Zare told CNN. “When droplets that have opposite charges are close together, electrons can jump from the negatively charged droplet to the positively charged droplet.”
The researchers mixed ammonia, carbon dioxide, methane and nitrogen in a glass bulb, then sprayed the gases with water mist, using a high-speed camera to capture faint flashes of microlightning in the vapor. When they examined the bulb’s contents, they found organic molecules with carbon-nitrogen bonds. These included the amino acid glycine and uracil, a nucleotide base in RNA.

“We discovered no new chemistry; we have actually reproduced all the chemistry that Miller and Urey did in 1953,” Zare said. Nor did the team discover new physics, he added — the experiments were based on known principles of electrostatics.

“What we have done, for the first time, is we have seen that little droplets, when they’re formed from water, actually emit light and get this spark,” Zare said. “That’s new. And that spark causes all types of chemical transformations.”

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