COVID-19 will be around for next 10 years, says BioNTech CEO Ugur Sahin

[Hungry_DinoBaby]

2 minutes ago, PilliBeta said:

It's ok, I like peanuts. 

[soodhilodaaram]

Just now, karthik25 said:

bhayya.. reference please.

GBS (Guillain-Barré Syndrome) and Vaccines | Vaccine Safety | CDC

GBS is rare... sure.. how rare 2%? 3%? they don't mention numbers here

[DummyVariable]

10 minutes ago, Hungry_DinoBaby said:

Konchem careful ga unte better

[soodhilodaaram]

28 minutes ago, PilliBeta said:

It's possible that some people may have worse effects than others if they take the vaccine. But I don't think I would say severe neurological disabilities. People have tried so hard but haven't found conclusive evidence tying autism to vaccines. 

please don't get into this political answers, there is enough data to show thimerosal is neurotoxin and all the symptoms of autism are common to mercury poisoning, why was thimerosal not taken out or there is no study in spite of so many taxpayers fighting for study on vaccine-autism link

Whistleblower Claims CDC Covered Up Data Showing Vaccine-Autism Link | Time

recent death of brandy vaughan and see her videos weeks prior to death, she is known voice in safe vaccines (get rid of toxic adjuvants)

 

[soodhilodaaram]

35 minutes ago, PilliBeta said:

Asalu nuvvu molecular biology chadivava? What is the central dogma of molecular biology? DNA to RNA to protein. Kada? So, how can RNA change DNA chemically?

Mol Biology chadavakkarledu.. basic common sense to think cheyali

looks like you have no clue on pharma and its history

vaccine does work, but adjuvants have totally destroyed the propose of vaccines

 

[soodhilodaaram]

41 minutes ago, PilliBeta said:

Actually the guy who made the pfizer vaccine published as his research with cancer, the design of his vaccine is also for cancer. With cancer, the problem is every person that has cancer will have different neoantigens. So, one vaccine will not work for everyone. That's the limitation of cancer vaccine. But as you can imagine, covid ki spike protein is the same. 

Asalu nuvvu post chesina article chadivava? It clearly says DNA encodes mRNA. But veelu use chese mRNA is modified such that protein production will increase ani...they never say mRNA changes DNA. Asalu biologically and chemically, how do you think RNA can change DNA, chemistry cheppu.

let me ask you

how do you think RNA can change DNA?? it cannot directly, but it can indirectly.. which needs to be studied first before screwing up 6B population

[PilliBeta]

5 minutes ago, soodhilodaaram said:

please don't get into this political answers, there is enough data to show thimerosal is neurotoxin and all the symptoms of autism are common to mercury poisoning, why was thimerosal not taken out or there is no study in spite of so many taxpayers fighting for study on vaccine-autism link

Whistleblower Claims CDC Covered Up Data Showing Vaccine-Autism Link | Time

recent death of brandy vaughan and see her videos weeks prior to death, she is known voice in safe vaccines (get rid of toxic adjuvants)

 

First off there is no conclusive evidence that thimerosal adjuvant causes autism. Despite that, most vaccines now do not use this adjuvant because of the spread of misinformation by people like you. Second off, the mRNA vaccine we are talking about doesn't use this adjuvant. Here are the ingredients: 

• Active Ingredient
  • nucleoside-modified messenger RNA (modRNA) encoding the viral spike glycoprotein (S) of SARS-CoV-2
• Lipids
  • (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis (ALC-3015)
  • (2- hexyldecanoate),2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159)
  • 1,2-distearoyl-snglycero-3-phosphocholine (DPSC)
  • cholesterol
• Salts
  • potassium chloride
  • monobasic potassium phosphate
  • sodium chloride
  • basic sodium phosphate dihydrate 
• Other
  • sucrose

[PilliBeta]

3 minutes ago, soodhilodaaram said:

let me ask you

how do you think RNA can change DNA?? it cannot directly, but it can indirectly.. which needs to be studied first before screwing up 6B population

How will RNA change DNA indirectly? Tell me the chemistry because I am not aware of this. 

[PilliBeta]

10 minutes ago, soodhilodaaram said:

Mol Biology chadavakkarledu.. basic common sense to think cheyali

looks like you have no clue on pharma and its history

vaccine does work, but adjuvants have totally destroyed the propose of vaccines

 

Adjuvant is used for vaccines that cannot be recognized by the immune system. In the past, there were chemical additives used in the design of some vaccines. mRNA is a strong adjuvant by itself since the immune cells already have transcription factors like TLR7 and TLR9 that can recognize mRNA. 

[PilliBeta]

21 minutes ago, soodhilodaaram said:

GBS (Guillain-Barré Syndrome) and Vaccines | Vaccine Safety | CDC

GBS is rare... sure.. how rare 2%? 3%? they don't mention numbers here

When there has been an increased risk, it has consistently been in the range of 1-2 additional GBS cases per million flu vaccine doses administered.

Studies suggest that it is more likely that a person will get GBS after getting the flu than after vaccination.

 

Man, do you know how many people we protect from getting the flu by giving them flu vaccine? How can the spread of misinformation be so rampant that people fail to realize the importance of vaccination? The only reason India got rid of polio is because of vaccination. How can any sensible person spread so much misinformation in the midst of a global pandemic?????? Like really. 

[perugu_vada]

1 hour ago, soodhilodaaram said:

let me ask you

how do you think RNA can change DNA?? it cannot directly, but it can indirectly.. which needs to be studied first before screwing up 6B population

http://scienceline.ucsb.edu/getkey.php?key=1647

To make genetic mutations you have to change DNA. RNA is generally "transcribed" or copied from the DNA template, which is like the master code. RNA is made in small pieces as needed, and there can be hundreds of times more RNA than DNA in a cell at any given time....but RNA is disposable and is degraded as soon as it is used. One way to think of this is that DNA is a textbook, RNA is a handout, and those handouts are used to get things done and then thrown out. If you change the handout, only a few people will be affected, but if you change the textbook then everyone will be affected forever. @soodhilodaaram uncle

i am neither chemist nor biology student, but have few friends who completed their ph.d’s in those depts and are ready to take up the vaccine whenever it is released

[karthik25]

2 hours ago, PilliBeta said:

Cancer lo each person has different antigen. Unless oka patient cancer sequence chesthe tappa vaccine design cheyaleru. Each person also gets a different personalized vaccine for cancer, not like COVID where everyone can get the same vaccine. 

Although cancer is individualistic, you can still divide patients in populations based on the oncogene/driver mutation and give treatment. Like HER2+ breast cancer patients for example. Still nothing worked. Closest is something in prostate cancer. 

[karthik25]

2 hours ago, PilliBeta said:

Asalu nuvvu molecular biology chadivava? What is the central dogma of molecular biology? DNA to RNA to protein. Kada? So, how can RNA change DNA chemically?

actually no. I have chemistry/pharmaceutical sciences background. Not biologicals. But the whole idea of mRNA as an intervention doesn't feel right. Of course, every great idea was brushed aside in the beginning. But in this case, I feel long term studies evaluating pharmacodynamics are necessary. There was no doubt that this virus is soon gonna mutate. Trying to make a one size fit all vaccine is not a idea. Happy to change my understanding though.

 

[PilliBeta]

12 minutes ago, karthik25 said:

Although cancer is individualistic, you can still divide patients in populations based on the oncogene/driver mutation and give treatment. Like HER2+ breast cancer patients for example. Still nothing worked. Closest is something in prostate cancer. 

The HER2 positive is just a type of cancer, not specifically the antigens. But yes, some tumor antigens will be similar among different patients. However, using tumor antigens as vaccines will not work too well because our body is more familiar with these antigens. In other words, if you give tumor antigens as vaccines, patients will build tolerance. That is why patient specific antigens aka neoantigens are what you need to target to generate a good immune response. In other words, you need to sequence each patient's tumor, figure out the tumor neoantigens, and then measure which of those bind with HLA of the patient to figure out what antigens should be used in cancer vaccines. @Anta AssameyAssamey knows how to do this. 

[PilliBeta]

10 minutes ago, karthik25 said:

actually no. I have chemistry/pharmaceutical sciences background. Not biologicals. But the whole idea of mRNA as an intervention doesn't feel right. Of course, every great idea was brushed aside in the beginning. But in this case, I feel long term studies evaluating pharmacodynamics are necessary. There was no doubt that this virus is soon gonna mutate. Trying to make a one size fit all vaccine is not a idea. Happy to change my understanding though.

 

It's not a one size fit for all. The mRNA is going to encode multiple antigens of the spike protein, even if the virus mutates in a few amino acids, there will still be ample number of antigens available because they are going to encode the entire spike protein.