N440K Covid variant 15 times more lethal

[cellphone]

South India's N440K Covid variant 15 times more lethal, getting replaced by double mutant, UK variants: Data

The variants with N440K spike substitution, believed to be 15 times more lethal than the earlier ones, have been detected in several parts of India. It is slowly getting replaced by double mutant, UK variants, dats shows.
 
Experts have said that the new prevalent variant, N440K is at least 15 times more lethal than the earlier ones (Reuters photo)
Several variants of SARS-CoV-2 have been emerging across the globe, continuing to threaten efforts to stem the world's worst virus outbreak. The variants with N440K spike substitution have been detected in several parts of India, which has been hit by the second wave of the pandemic.

Scientists at the Centre for Cellular and Molecular Biology (CCMB) have found that lineages with N440K are not the dominant ones in the second wave of the coronavirus pandemic in India. It was CCMB that had discovered the new coronavirus variant N440K.

Experts have also said that the new prevalent variant, N440K is at least 15 times more lethal than the earlier ones. They said it may even be stronger than the Indian variants of B1.617 and B1.618.

While N440K was indeed a mutation of concern in South India during and after the first wave, current data shows that it is slowly being replaced by new variants of concerns (VoCs) such as B.1.617 (dubbed a double-mutant variant) and B.1.1.7 (variant identified in the UK).

When comparing the data from Maharashtra, researchers found that the increase of B.1.617 variant was in February rather than in March 2021, and again a reduction in the proportion of lineages with N440K was observed.

"The timing of the increase in B.1.617 coincides well with the second waves seen in the respective states," finds Divya Tej Sowpati of CCMB.

According to him, in Maharastra, one of the worst-affected states in the country, the second wave started almost a month and half earlier compared to the four southern states, along with the explosion of B.1.617 at the expense of lineages with the mutation N440K.

"In Kerala, though not much data is available on GISAID, we can see from genescov2.genomes.in that B.1.1.7 is increasing at present, whereas N440K is present in less than 20 per cent of the genomes," he further added.

Earlier, CCMB scientists had found that the N440K variant produced ten times higher infectious viral titers than a prevalent A2a strain, and over 1,000 folds higher titers than a much less prevalent A3i strain prototype in Caco2 cells.

However, this may not be a matter of concern, because how a virus behaves in cell culture under controlled settings and no competition, may not be the same in a complicated pandemic scenario.

Earlier, by June 2020, a variant with D614G substitution had become the predominant strain. Later, new variants were identified across the world, such as the B.1.1.7 lineage (UK), P.1 lineage (Brazil), and B.1.351 (South Africa).

[reality]

Who are giving these naming conventions?

Karnool variant, Lakdikapool variant... 

Panikoche pani emanna cheyandra ante... fear mongering..

[Azure]

1 minute ago, cellphone said:

South India's N440K Covid variant 15 times more lethal, getting replaced by double mutant, UK variants: Data

The variants with N440K spike substitution, believed to be 15 times more lethal than the earlier ones, have been detected in several parts of India. It is slowly getting replaced by double mutant, UK variants, dats shows.
 
Experts have said that the new prevalent variant, N440K is at least 15 times more lethal than the earlier ones (Reuters photo)
Several variants of SARS-CoV-2 have been emerging across the globe, continuing to threaten efforts to stem the world's worst virus outbreak. The variants with N440K spike substitution have been detected in several parts of India, which has been hit by the second wave of the pandemic.

Scientists at the Centre for Cellular and Molecular Biology (CCMB) have found that lineages with N440K are not the dominant ones in the second wave of the coronavirus pandemic in India. It was CCMB that had discovered the new coronavirus variant N440K.

Experts have also said that the new prevalent variant, N440K is at least 15 times more lethal than the earlier ones. They said it may even be stronger than the Indian variants of B1.617 and B1.618.

While N440K was indeed a mutation of concern in South India during and after the first wave, current data shows that it is slowly being replaced by new variants of concerns (VoCs) such as B.1.617 (dubbed a double-mutant variant) and B.1.1.7 (variant identified in the UK).

When comparing the data from Maharashtra, researchers found that the increase of B.1.617 variant was in February rather than in March 2021, and again a reduction in the proportion of lineages with N440K was observed.

"The timing of the increase in B.1.617 coincides well with the second waves seen in the respective states," finds Divya Tej Sowpati of CCMB.

According to him, in Maharastra, one of the worst-affected states in the country, the second wave started almost a month and half earlier compared to the four southern states, along with the explosion of B.1.617 at the expense of lineages with the mutation N440K.

"In Kerala, though not much data is available on GISAID, we can see from genescov2.genomes.in that B.1.1.7 is increasing at present, whereas N440K is present in less than 20 per cent of the genomes," he further added.

Earlier, CCMB scientists had found that the N440K variant produced ten times higher infectious viral titers than a prevalent A2a strain, and over 1,000 folds higher titers than a much less prevalent A3i strain prototype in Caco2 cells.

However, this may not be a matter of concern, because how a virus behaves in cell culture under controlled settings and no competition, may not be the same in a complicated pandemic scenario.

Earlier, by June 2020, a variant with D614G substitution had become the predominant strain. Later, new variants were identified across the world, such as the B.1.1.7 lineage (UK), P.1 lineage (Brazil), and B.1.351 (South Africa).

Anna again credit to India ?

[cellphone]

Just now, reality said:

Who are giving these naming conventions?

Karnool variant, Lakdikapool variant... 

Panikoche pani emanna cheyandra ante... fear mongering..

bhaya pedadam ani kadu.. india lo chala mandi inka careless ga tirugutunnaru..just posting the information. India lo vunnollaki telustadi reality. 

[cellphone]

While it is too early to state whether the new coronavirus variant discovered by CCMB (Centre for Cellular and Molecular Biology) N440K, is the variant that is creating havoc in Visakhapatnam and other parts of the State, experts say the new prevalent variant, which is being called as the AP variant as it was first discovered in Kurnool, is at least 15 times more virulent than the earlier ones, and may be even stronger than the Indian variants of B1.617 and B1.618.

[cellphone]

this information was collected from internet. naming nenu ivaledu.. chill

[reality]

Just now, cellphone said:

bhaya pedadam ani kadu.. india lo chala mandi inka careless ga tirugutunnaru..just posting the information. India lo vunnollaki telustadi reality. 

nuvvu post esinanduku anadam ledhu... but, aa naming conventions endhi ani... Manollu etla ante... Oh Karnool lone deadly variant undhi ata ani.. inko daggara light thiskunte type...

[cellphone]

1 minute ago, reality said:

nuvvu post esinanduku anadam ledhu... but, aa naming conventions endhi ani... Manollu etla ante... Oh Karnool lone deadly variant undhi ata ani.. inko daggara light thiskunte type...

anduke clear ga topic vesina

[The_Captain]

Hope India is already in mild third wave with this so called new variants(second wave Feb this year in MH with B1.617) and this pandemic is done in the coming 2 weeks or a month at least. 

praying for everyone, God please stop this 🙏

 

[AWS]

India become production unit

[FLraja]

8 minutes ago, AWS said:

India become production unit

Mee data enter vunda

[no01]

2 hours ago, The_Captain said:

Hope India is already in mild third wave with this so called new variants(second wave Feb this year in MH with B1.617) and this pandemic is done in the coming 2 weeks or a month at least. 

praying for everyone, God please stop this 🙏

 

3rd wave ki inka time undi annaru...between Oct-Dec lo ravochu ani talk...and it will have massive attack on kids and teens ani hyd lo frnds saying...dont know how true it is but heard from 3 different ppl

[PizzaReddy]

Made ion India ni serious teesukunna Bhakths antunna @8pm

[8pm]

4 minutes ago, PizzaReddy said:

Made ion India ni serious teesukunna Bhakths antunna @8pm

[trent]

https://www.newindianexpress.com/states/andhra-pradesh/2021/may/03/no-need-to-panic-over-n440k-variant-of-covid-19-says-expert-2298005.html
 

no need to panic