where is pillibeta ? ; UC Berkeley loses CRISPR patent case, invalidating licenses it granted gene-editing companies

[Dabbakai]

Ending the latest chapter in a years-long legal battle over who invented CRISPR, the US Patent and Trademark Office ruled on Monday that the revolutionary genome editing technology belongs to the Broad Institute of Harvard and MIT.

The decision is a huge blow to the University of California and biotech companies that had licensed the technology from the university for use in developing treatments, including Intellia Therapeutics and CRISPR Therapeutics. They will now have to negotiate with the Broad Institute for the right to use CRISPR for human therapies.

“This is pretty bad news for anyone who has a license for Berkeley’s technology,” said Jacob Sherkow, a patent attorney and professor at the University of Illinois College of Law who has closely followed the fight. “They have over 100 patent claims that just got wiped off the face of the earth.”

In 2020, Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier of the Max Planck Institute for Infection Biology were awarded the Nobel Prize in Chemistry for first describing how CRISPR could be used to edit DNA, which they showed in a paper published in Science on June 28, 2012.

But that paper was focused on gene-editing in a test tube. The issue in this case was determining which team was first to get CRISPR to work in eukaryotic cells — a crucial step to translating the technology into treatments for human disease. A Broad group led by Feng Zhang reported in a Jan. 3, 2013, paper in Science that it had successfully CRISPR’d both mouse and human cells.

The University of California was joined in bringing the latest case by the University of Vienna and Charpentier — called the CVC group in legal filings.

CRISPR is made up of two components — an enzyme that cuts DNA and a guide RNA that acts like a GPS system, telling that enzyme where to go. In oral arguments before the Patent Trial and Appeal Board earlier this month, CVC attorney Eldora Ellison contended that the guide RNA Doudna and Charpentier described in their 2012 paper was essential for getting CRISPR to work in eukaryotic cells. And that the Broad team, led by Zhang, only succeeded after seeing the Berkeley team’s work.

“The law is clear,” Ellison said at the virtual hearing. “You cannot take someone else’s idea, try to throw a patent on it, then spend 10 years claiming you’re the inventor.”

But the Patent Trial and Appeal Board decided that CVC failed to provide convincing evidence that Doudna and Charpentier’s teams beat Zhang’s to the finish line. “Thus, we determine CVC’s currently involved claims are unpatentable,” they wrote in an 84-page decision.

“Today’s USPTO ruling is surprising and contrary to what more that 30 countries and the Nobel Prize Committee have decided regarding the invention of CRISPR-Cas9 genome engineering technology for use in all cell types, including human cells,” Doudna told STAT via e-mail. “This latest decision will be appealed.”

Zhang was not immediately available for comment. A statement from the Broad Institute emphasized that the latest decision “once again confirmed Broad’s patents were properly issued.”

[Tomb__ayya]

Matter in 2 or 3 lines fleezzz

[Dabbakai]

6 minutes ago, Tomb__ayya said:

Matter in 2 or 3 lines fleezzz

emundii gene editing muchata ki oka group vallaki nobel ochchindii thats for their research in prokaryotes(microbes like amoeba), Zhang ane researcher Eukaryotes paina chesindu (mammalian cells) 

iddaru  patents apply chesinru but Zhang ki ichchinru anta after much of kotlata. 

pillibeta was sad for zhang not able to get nobel so now she might be happy for zhang

[Spartan]

@Anta Assamey

[Tomb__ayya]

2 hours ago, Dabbakai said:

emundii gene editing muchata ki oka group vallaki nobel ochchindii thats for their research in prokaryotes(microbes like amoeba), Zhang ane researcher Eukaryotes paina chesindu (mammalian cells) 

iddaru  patents apply chesinru but Zhang ki ichchinru anta after much of kotlata. 

pillibeta was sad for zhang not able to get nobel so now she might be happy for zhang

ante ippudu common amoebiasis microbial infection vasthadi kada, dhanni kochem edit chesi, gain of function tho ingo pandemic kosram e 10gulaata na, e sari for a change virus ku badhulu bacteria/protozoa using aa ?

[Spartan]

3 minutes ago, Tomb__ayya said:

ante ippudu common amoebiasis microbial infection vasthadi kada, dhanni kochem edit chesi, gain of function tho ingo pandemic kosram e 10gulaata na, e sari for a change virus ku badhulu bacteria/protozoa using aa ?

anna Virus aite tattukogalam kaani bacterial infection ante chaala kashtam

[Dabbakai]

2 minutes ago, Spartan said:

anna Virus aite tattukogalam kaani bacterial infection ante chaala kashtam

enduku anni bacterial infections ki meropenum aka water aka antibiotic vundii kada ani @Tomb__ayya cheppamannadu 

[Tomb__ayya]

Just now, Spartan said:

anna Virus aite tattukogalam kaani bacterial infection ante chaala kashtam

kadhanna virus tho hardly 0.5% population impact ayindhi ga, e saari konchem gattiga plan chesaremo.

chesinaa chestharu, we never know . . bill uncle hinted last month about next pandemic . . . 

em cheyalem kada, edaithe adhi ayithe, unte untam pothe potham . . . 

 

[Tomb__ayya]

2 minutes ago, Dabbakai said:

enduku anni bacterial infections ki meropenum aka water aka antibiotic vundii kada ani @Tomb__ayya cheppamannadu 

GoF ku antha karchupetti, antibiotics ku treat ayye infection tho sketch esthara